Genetics and environment distinctively shape the human immune cell epigenome.

doi:10.1038/s41588-025-02479-6

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Article

Genetics and environment distinctively shape the human immune cell epigenome.

Nature genetics - 1 Feb 2026

Wang Wenliang, Hariharan Manoj, Ding Wubin, Bartlett Anna, Barragan Cesar, Castanon Rosa, Wang Ruoxuan, Rothenberg Vince, Song Haili, Nery Joseph R, Aldridge Andrew, Altshul Jordan, Kenworthy Mia, Liu Hanqing, Tian Wei, Zhou Jingtian, Zeng Qiurui, Chen Huaming, Wei Bei, Gündüz Irem B, Norell Todd, Broderick Timothy J, McClain Micah T, Satterwhite Lisa L, Burke Thomas W, Petzold Elizabeth A, Shen Xiling, Woods Christopher W, Fowler Vance G, Ruffin Felicia, Panuwet Parinya, Barr Dana B, Beare Jennifer L, Smith Anthony K, Spurbeck Rachel R, Vangeti Sindhu, Ramos Irene, Nudelman German, Sealfon Stuart C, Castellino Flora, Walley Anna Maria, Evans Thomas, Müller Fabian, Greenleaf William J, Ecker Joseph R

Abstract excerpt

The epigenome of human immune cells is shaped by both genetics and environmental factors, yet the relative contributions of these influences remain incompletely characterized. Here we use single-nucleus methylation sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-seq) to systematically explore how pathogen and chemical exposures, along with genetic variation, are associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41593234
DOI: 10.1038/s41588-025-02479-6
PMCID: PMC12900638

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