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Article

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions.

Blood - 12 Dec 2013

Zilbauer Matthias, Rayner Tim F, Clark Christine, Coffey Alison J, Joyce Chris J, Palta Priit, Palotie Aarno, Lyons Paul A, Smith Kenneth G C

Abstract excerpt

DNA methylation is an important mechanism by which gene transcription and hence cellular function are regulated. Here, we provide detailed functional genome-wide methylome maps of 5 primary peripheral blood leukocyte subsets including T cells, B cells, monocytes/macrophages, and neutrophils obtained from healthy individuals. A comparison of these methylomes revealed highly specific cell-lineage and cell-subset...

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Identifiers

PMID: 24159175
DOI: 10.1182/blood-2013-05-503201
PMCID: PMC3862273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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