Article

Human iPSC-derived prostate organoids with germline BRCA2 mutation undergo tumorigenic transformations

2025-08-31

Abstract excerpt

The lack of physiologically relevant in vitro prostate models has impeded studies of organ development and prostate tumorigenesis. We reprogrammed peripheral blood mononuclear cells (PBMCs) from individuals with and without pathogenic-germline BRCA2 mutation (MUT_BRCA2, CON_BRCA2) into induced pluripotent stem cells (iPSCs), which showed no differences in morphology, proliferation, or pluripotency markers. Differe...

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Literature Corpus work: d75f8de7-13e8-5a4f-9d35-7a22761f7419
DOI: 10.1101/2025.08.26.672478

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