Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-loss

Abstract excerpt

<h4>Summary</h4> Prostate cancer (PCa) is the second most common cancer in men and shows high inter- and intra-patient heterogeneity. Consequently, treatment options are limited and there is a lack of representative preclinical models. Here we establish a comprehensive biobank of murine organoids and tumoroids that reflect common patient mutations. We demonstrate that the deletion of Pten alone, or in combinatio...

Topics

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• 14-3-3 protein interactions
• Androgen Antagonists
• Cancer Cells and Metastasis
• Cancer Genomics and Diagnostics
• Epithelial-Mesenchymal Transition
• Prostate Cancer Treatment and Research
• Receptors, Androgen
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

283e82fa-fe97-5fee-becd-9fc5fdce9c78

DOI

10.1101/2025.03.14.643296