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Article

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses.

Journal of visualized experiments : JoVE - 24 Oct 2019

Pappas Kyrie J, Choi Danielle, Sawyers Charles L, Karthaus Wouter R

Abstract excerpt

Presented here is a protocol to study pharmacodynamics, stem cell potential, and cancer differentiation in prostate epithelial organoids. Prostate organoids are androgen responsive, three-dimensional (3D) cultures grown in a defined medium that resembles the prostatic epithelium. Prostate organoids can be established from wild-type and genetically engineered mouse models, benign human tissue, and advanced...

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Identifiers

PMID: 31710046
DOI: 10.3791/60346
PMCID: PMC7318111

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