Article

Patient-derived prostate cancer organoids require α6-integrins for self-renewal and recapitulate genetic heterogeneity and histopathology of the original tumors

2023-08-08

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Modeling the pathophysiology of prostate cancer (PCa) remains a challenge and primary tissue-derived organoid cultures have emerged as promising models representing good tissue mimicry. <bold>Methods:</bold> We have established 36 PCa patient-derived organoid cultures that self-renew and can be maintained long-term. Using CRISPR-mediated genomic editing, selecte...

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Literature Corpus work: 8c7e55dd-5bd4-52d2-a28b-5b9995704a19
DOI: 10.21203/rs.3.rs-3209780/v1

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Patient-derived prostate cancer organoids require α6-integrins for self-renewal and recapitulate genetic heterogeneity and histopathology of the original tumorsDOI 10.21203/rs.3.rs-3209780/v1Read

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