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Article

Multi-omics evaluation of cell lines as models for metastatic prostate cancer.

Communications biology - 24 Mar 2026

Liu Xueying, Yu Weixing, Jin Xiuyuan, Wang Yugang, Liu Ke

Abstract excerpt

Cell lines are indispensable tools in prostate cancer research yet their suitability as models for distance metastasis remains incompletely characterized. Here, we conduct a systematic evaluation study using large-scale public multi-omics data. We reveal substantial genomic differences between cell lines and metastatic patient samples, and meanwhile pinpoint cell lines which more closely resemble metastatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41876625
DOI: 10.1038/s42003-026-09914-2
PMCID: PMC13171877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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