Article

Xeno-free human iPSC-derived prostate organoid platform for multilineage differentiation and genetic manipulation

2025-10-22

Abstract excerpt

Current prostate organoid models rely on tissue-derived material or animal components and lack epithelial and stromal complexity. We defined a xeno-free system to generate human prostate organoids from induced pluripotent stem cells with consistent multilineage differentiation. Floating organoids self-organize into epithelial and stromal domains with basal, luminal, neuroendocrine, fibroblast, and smooth muscle ma...

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Literature Corpus work: fe5ccbb9-a2e6-5b07-92b0-ed950a48afec
DOI: 10.1101/2025.10.21.683654

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