Article

ECM-free patient-derived organoids preserve diverse prostate cancer lineages and uncover <i>in vitro</i> -enriched cell types

2024-10-18

Abstract excerpt

Patient-derived organoids (PDOs) offer new opportunities to model various cancers. However, their application in prostate cancer (PCa) has been hampered by poor success rates and overgrowth of cell types which are not representative of the patient samples. By exploiting a cohort of 164 PCa patient samples and tuning several culture parameters, we show that an extracellular matrix-free (ECM)-free culture system inc...

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Literature Corpus work: 1410b883-6ed7-5f65-af29-18f1b941061c
DOI: 10.1101/2024.10.16.618617

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