Article

<i>De novo</i> nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: Relevance to migraine and other headache disorders

2025-08-19

Abstract excerpt

ATP-sensitive potassium (K ATP ) channel opener levcromakalim is a potent inducer of vasodilation, headache, and migraine attacks in humans and tactile hypersensitivity in mice. Other migraine-inducing agents such as nitric oxide (NO) donors, CGRP, and PACAP are thought to activate second messengers leading to K ATP opening. Yet, how K ATP channel opening leads to migraine remains unclear. Here, we investigated...

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Literature Corpus work: d70d0ee7-7c94-5c8b-9752-f3f1961dbd46
DOI: 10.1101/2025.08.15.670471

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