Article

PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine

2022-08-11

Abstract excerpt

<h4>Background: </h4> Calcitonin gene-related peptide (CGRP) antagonizing drugs represents the most important advance in migraine therapy for decades. However, these new drugs are only effective in 50–60% of patients. Recent studies have shown that the pituitary adenylate cyclase-activating peptide (PACAP38) pathway is independent from the CGRP signaling pathway. Here, we investigate PACAP38 signaling pathways in...

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Literature Corpus work: 461371b8-a595-52d6-8307-1728eb804cf2
DOI: 10.21203/rs.3.rs-1922959/v1

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