Article
Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation.
Molecular pain - 14 Mar 2009
Kawano Takashi, Zoga Vasiliki, Kimura Masakazu, Liang Mei-Ying, Wu Hsiang-En, Gemes Geza, McCallum J Bruce, Kwok Wai-Meng, Hogan Quinn H, Sarantopoulos Constantine D
Abstract excerpt
BACKGROUND: ATP-sensitive potassium (KATP) channels in neurons regulate excitability, neurotransmitter release and mediate protection from cell-death. Furthermore, activation of KATP channels is suppressed in DRG neurons after painful-like nerve injury. NO-dependent mechanisms modulate both KATP channels and participate in the pathophysiology and pharmacology of neuropathic pain. Therefore, we investigated NO...
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