Article

CGRP Signals from Endosomes of Schwann Cells to Elicit Migraine Pain

2021-08-24

Abstract excerpt

<title>Abstract</title> <p>Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain. However, the site and mechanism of CGRP-evoked migraine pain remain unknown. By cell-selective RAMP1 gene deletion, we reveal that CGRP released from m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46a0cca0-e44b-54eb-b782-0684cb197a7f
DOI: 10.21203/rs.3.rs-758153/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CGRP Signals from Endosomes of Schwann Cells to Elicit Migraine PainDOI 10.21203/rs.3.rs-758153/v1Read

Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic PainSemantic proximity Read

Non-neuronal TRPA1 encodes mechanical allodynia evoked by neurogenic inflammation and partial nerve injury in ratsSemantic proximity Read

Atogepant: Mechanism of action, clinical and translational scienceSemantic proximity Read

Concise review: Current understanding of extracellular vesicles to treat neuropathic painSemantic proximity Read

Disentangling Schwann Cell and Neuronal TRPA1 Function in Mouse Models of Familial Episodic Pain SyndromeSemantic proximity Read

Schwann cell release of p11 induces sensory neuron hyperactivity in Fabry diseaseSemantic proximity Read

Keratinocyte expression of calcitonin gene-related peptide β: Implications for neuropathic and inflammatory pain mechanismsSemantic proximity Read

Essential role of Ret for defining non-peptidergic nociceptor phenotypes and functions in the adult mouse.Semantic proximity Read

Effects of LPS on P2X3 receptors of trigeminal sensory neurons and macrophages from mice expressing the R192Q Cacna1a gene mutation of familial hemiplegic migraine-1.Semantic proximity Read

Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neuronsSemantic proximity Read

Satellite glial GPR37L1 regulates maresin and potassium channel signaling for pain controlSemantic proximity Read

A G protein-coupled receptor is essential for Schwann cells to initiate myelination.Semantic proximity Read