Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells.

Pflugers Archiv : European journal of physiology - 1 Jun 2010

Wong Ching-On, Sukumar Piruthivi, Beech David J, Yao Xiaoqiang

Abstract excerpt

TRPC5 is a member of the canonical transient receptor potential (TRPC) family of proteins that forms cationic channels either through homomultimeric assembly or heteromultimeric coordination with other TRPC proteins. It is expressed in a variety of cells including central neurones and endothelial cells and has susceptibility to stimulation by multiple factors. Here we investigated if TRPC5 is sensitive to nitric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Signaling
Share to Cyclic GMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fluorometry

Share to Membrane Potentials

Share to Nitric Oxide

Share to Nitric Oxide Donors

Share to TRPC Cation Channels

Share to TRPC6 Cation Channel

Source

Open in PubMed Open full text

Identifiers

PMID: 20390293
DOI: 10.1007/s00424-010-0823-3
PMCID: PMC3622007

Genes

TRPC5
TRPC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells.PMID 20390293Read ↗

TRPC5.Semantic proximity Read ↗

Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6.Semantic proximity Read ↗

Transient receptor potential channel C5 in cancer chemoresistance.Semantic proximity Read ↗

<i>De novo</i> nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: Relevance to migraine and other headache disordersSemantic proximity Read ↗

Heteromeric TRPV4-C1 channels contribute to store-operated Ca(2+) entry in vascular endothelial cells.Semantic proximity Read ↗

Formation of novel TRPC channels by complex subunit interactions in embryonic brain.Semantic proximity Read ↗

Heteromultimeric TRPC6-TRPC7 channels contribute to arginine vasopressin-induced cation current of A7r5 vascular smooth muscle cells.Semantic proximity Read ↗

Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production.Semantic proximity Read ↗

Transient receptor potential canonical 7: a diacylglycerol-activated non-selective cation channel.Semantic proximity Read ↗

Evaluation of podocyte Rac-1 induced kidney disease by modulation of TRPC5Semantic proximity Read ↗

Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.Semantic proximity Read ↗

Riluzole activates TRPC5 channels independently of PLC activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.