Article
Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production.
Blood - 15 Jul 2004
Gilchrist Mark, McCauley Scott D, Befus A Dean
Abstract excerpt
Nitric oxide (NO) is a potent radical produced by nitric oxide synthase (NOS) and has pleiotrophic activities in health and disease. As mast cells (MCs) play a central role in both homeostasis and pathology, we investigated NOS expression and NO production in human MC populations. Endothelial NOS (eNOS) was ubiquitously expressed in both human MC lines and skin-derived MCs, while neuronal NOS (nNOS) was variably...
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