Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice.

PloS one - 13 Dec 2010

Hervera Arnau, Negrete Roger, Leánez Sergi, Martín-Campos Jesús M, Pol Olga

Abstract excerpt

BACKGROUND: Nitric oxide generated by neuronal (NOS1), inducible (NOS2) or endothelial (NOS3) nitric oxide synthases contributes to pain processing, but the exact role of NOS1 and NOS2 in the maintenance of chronic peripheral neuropathic pain as well as the possible compensatory changes in their expression in the spinal cord of wild type (WT) and NOS knockout (KO) mice at 21 days after total sciatic nerve...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Enzymologic
Share to Hot Temperature

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hyperalgesia

Share to Nitric Oxide Synthase Type I

Share to Nitric Oxide Synthase Type II

Share to Nitric Oxide Synthase Type III

Share to Spinal Cord

Source

Open in PubMed Open full text

Identifiers

PMID: 21179208
DOI: 10.1371/journal.pone.0014321
PMCID: PMC3001461

Genes

NOS1
NOS2
NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice.PMID 21179208Read ↗

Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS.Semantic proximity Read ↗

Nitric oxide in cellular adaptation and diseaseSemantic proximity Read ↗

Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice.Semantic proximity Read ↗

<i>De novo</i> nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: Relevance to migraine and other headache disordersSemantic proximity Read ↗

Non-neuronal TRPA1 encodes mechanical allodynia evoked by neurogenic inflammation and partial nerve injury in ratsSemantic proximity Read ↗

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.Semantic proximity Read ↗

Pre-Injury Mechanoreceptor Ablation Reduces Nociceptor-Driven Spinal Cord Injury-Induced Neuropathic PainSemantic proximity Read ↗

Repressor element 1–silencing transcription factor drives the development of chronic pain statesSemantic proximity Read ↗

Application of ultrahigh frequency transcutaneous electrical nerve stimulation for alleviation of neuropathic pain and neuroinflammation modulation in rat sciatic nerve chronic constriction injurySemantic proximity Read ↗

Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms.Semantic proximity Read ↗

Enhanced astrocytic nitric oxide production and neuronal modifications in the neocortex of a NOS2 mutant mouse.Semantic proximity Read ↗

Differential Spinal Cord Gene Expression in Rodent Models of Radicular and Neuropathic PainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.