Article
Effects of LPS on P2X3 receptors of trigeminal sensory neurons and macrophages from mice expressing the R192Q Cacna1a gene mutation of familial hemiplegic migraine-1.
Purinergic signalling - 1 Mar 2013
Franceschini Alessia, Hullugundi Swathi K, van den Maagdenberg Arn M J M, Nistri Andrea, Fabbretti Elsa
Abstract excerpt
A knockin (KI) mouse model with the R192Q missense mutation in the Cacna1a gene commonly detected in familial hemiplegic migraine was used to study whether trigeminal ganglia showed a basal inflammatory profile that could be further enhanced by the lipopolysaccharide (LPS) toxin. Adenosine-5'-triphosphate (ATP)-gated purinergic ionotropic receptor 3 (P2X3) currents expressed by the large majority of trigeminal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.