Article

ADAM17 is the Principal Ectodomain Sheddase of the EGF-Receptor Ligand Amphiregulin

2017-11-13

Abstract excerpt

The epidermal growth factor (EGF)-receptor ligand amphiregulin (AREG) is a potent growth factor implicated in proliferative skin diseases and in primary and metastatic epithelial cancers. AREG in vitro , synthesized as a pro-peptide, requires conversion to an active peptide by metalloproteases by a process known as ectodomain shedding. Although, (Adam17) a disintegrin and metalloprotease 17 is implicated in ectod...

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Literature Corpus work: d70b0d1c-c63e-5b67-b1ba-97dc17d39f24
DOI: 10.1101/218891

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