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Article

ADAM17 transactivates EGFR signaling during embryonic eyelid closure.

Investigative ophthalmology & visual science - 7 Jan 2013

Hassemer Eryn L, Endres Bradley, Toonen Joseph A, Ronchetti Adam, Dubielzig Richard, Sidjanin Duska J

Abstract excerpt

PURPOSE: During mammalian embryonic eyelid closure ADAM17 has been proposed to play a role as a transactivator of epidermal growth factor receptor (EGFR) signaling by shedding membrane bound EGFR ligands. However, ADAM17 also sheds numerous other ligands, thus implicating ADAM17 in additional molecular pathways. The goal of this study was to experimentally establish the role of ADAM17 and determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23211830
DOI: 10.1167/iovs.12-11130
PMCID: PMC3544417

Genes

ADAM17
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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