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Article

Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease.

BMC research notes - 7 Nov 2017

Hosur Vishnu, Lyons Bonnie L, Burzenski Lisa M, Shultz Leonard D

Abstract excerpt

OBJECTIVE: Gain-of-function (GOF) mutations in RHBDF2 cause tylosis. Patients present with hyperproliferative skin, and keratinocytes from tylosis patients' skin show an enhanced wound-healing phenotype. The curly bare mouse model of tylosis, carrying a GOF mutation in the Rhbdf2 gene (Rhbdf2 cub ), presents with epidermal hyperplasia and shows accelerated cutaneous wound-healing phenotype through enhanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29116018
DOI: 10.1186/s13104-017-2899-8
PMCID: PMC5678570

Genes

RHBDF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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