Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.

Abstract excerpt

All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases. In several instances, ectodomain release is critical for activation of EGFR ligands, highlighting the importance of identifying EGFR ligand sheddases. Here, we uncovered the sheddases for six EGFR ligands using mouse embryonic cells lacking...

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• ADAM Proteins
• ADAM17 Protein
• Aspartic Acid Endopeptidases
• Heparin-binding EGF-like Growth Factor
• Protease Inhibitors