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Article

Cell surface annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin

23 Mar 2012

Abstract excerpt

A disintegrin and metalloproteinase (ADAM) is a family of enzymes involved in ectodomain shedding of various membrane proteins. However, the molecular mechanism underlying substrate recognition by ADAMs remains unknown. In this study, we successfully captured and analyzed cell surface transient assemblies between the transmembrane amphiregulin precursor (proAREG) and ADAM17 during an early shedding phase, which...

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PMID: 22438584
DOI: 10.1091/mbc.e11-08-0683

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