Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

4 Jan 2011

Abstract excerpt

The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and homeostasis. To address the in vivo relevance of Adam10 in the epidermis, we have selectively disrupted Adam10 during skin morphogenesis and in adult skin. K14-Cre driven epidermal Adam10 deletion leads to perinatal lethality, barrier impairment and absence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Hair Growth and Disorders
Share to Skin and Cellular Biology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21205794
DOI: 10.1242/dev.055210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signalingPMID 21205794Read ↗

ADAM10: Function insights, disease implications, and promise of therapeutic targetingSemantic proximity Read ↗

Emerging roles for ADAMTS5 during development and disease.Semantic proximity Read ↗

Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice.Semantic proximity Read ↗

Genetic Requirement for ADAM10 in Severe Staphylococcus aureus Skin InfectionSemantic proximity Read ↗

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.Semantic proximity Read ↗

Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8Semantic proximity Read ↗

Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract developmentSemantic proximity Read ↗

A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.Semantic proximity Read ↗

Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype.Semantic proximity Read ↗

Secreted protease ADAMTS18 in development and diseaseSemantic proximity Read ↗

An Overview of ADAM9: Structure, Activation, and Regulation in Human DiseasesSemantic proximity Read ↗

The secreted metalloprotease ADAMTS20 is required for melanoblast survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.