Single-cell whole-genome sequencing reveals convergent evolution in Burkitt lymphoma

Abstract excerpt

Burkitt lymphoma (BL) carries multiple oncogenic drivers yet arises predominantly in children, whose normal cells harbour few age-related mutations. To investigate this paradox, we sought to define the sequence and timing of mutational drivers underlying BL development. Here, we analysed single-cell whole-genome sequencing (WGS) data of 250 paired normal and malignant B-cells from BL patients and integrated this d...

Topics

Open a Topic to create a Post that cites this publication.

• B-Lymphocytes
• Burkitt Lymphoma
• DNA Copy Number Variations
• Evolution, Molecular
• Phylogeny
• Point Mutation
• Single-Cell Analysis
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

d709509b-71c8-53a8-a5d3-fc45cf88dce4

DOI

10.64898/2025.12.12.692552