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Article

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

29 Mar 2019

Abstract excerpt

Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation. Moreover, by mapping IGH...

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PMID: 30926794
DOI: 10.1038/s41467-019-08578-3

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