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Article

Single-cell whole-genome sequencing reveals convergent evolution in Burkitt lymphoma.

Nature communications - 8 Jun 2026

Steemers Alexander S, van Roosmalen Markus J, Hagelaar Rico, Trabut Laurianne, Verheul Mark, de Kanter Jurrian K, Jongsma Siem, Derks Lucca L M, Blackwell Alexander R, Meyer-Wentrup Friederike, van Boxtel Ruben

Abstract excerpt

Burkitt lymphoma carries multiple oncogenic drivers yet arises predominantly in children, whose normal cells harbour few age-related mutations. To investigate this paradox, we seek to define the sequence and timing of mutational drivers underlying Burkitt lymphoma development. Here, we analyse single-cell whole-genome sequencing data of 250 paired normal and malignant B-cells from Burkitt lymphoma patients and...

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Identifiers

PMID: 42259789
DOI: 10.1038/s41467-026-74121-w
PMCID: PMC13402838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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