Article

Restoring Shank3 in a rostral sensorimotor brainstem nucleus rescues reduced light-evoked behaviors in shank3ab-/- zebrafish.

2021-03-22

Abstract excerpt

<title>Abstract</title> People with Phelan-McDermid Syndrome, caused by mutations in the SHANK3 gene, commonly present with symptoms of sensory hyporeactivity. To investigate how shank3 mutations impact brain circuits and contribute to sensory hyporeactivity, we generated two shank3 zebrafish mutant models. These shank3 mutant models both exhibit hyporeactivity to visual stimuli. Using whole-brain activity map...

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Literature Corpus work: d6de8e13-ced1-5f60-8b35-8c87707bfcf5
DOI: 10.21203/rs.3.rs-83115/v1

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