Article

Somatosensory processing deficits and altered cortico-hippocampal connectivity in <i> Shank3b <sup>−/−</sup> </i> mice

2021-02-28

Abstract excerpt

Abnormal tactile response is considered an integral feature of Autism Spectrum Disorders (ASDs), and hypo-responsiveness to tactile stimuli is often associated with the severity of ASDs core symptoms. Patients with Phelan-McDermid syndrome (PMS), caused by mutations in the SHANK3 gene, show ASD-like symptoms associated with aberrant tactile responses. However, the neural underpinnings of these somatosensory abnorm...

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Literature Corpus work: 7280b873-793d-5a91-a2dd-57f91a82a92f
DOI: 10.1101/2021.02.28.433258

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