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Article

Restoring Shank3 in the rostral brainstem of shank3ab-/- zebrafish autism models rescues sensory deficits.

Communications biology - 17 Dec 2021

Kozol Robert A, James David M, Varela Ivan, Sumathipala Sureni H, Züchner Stephan, Dallman Julia E

Abstract excerpt

People with Phelan-McDermid Syndrome, caused by mutations in the SHANK3 gene, commonly exhibit reduced responses to sensory stimuli; yet the changes in brain-wide activity that link these symptoms to mutations in the shank3 gene remain unknown. Here we quantify movement in response to sudden darkness in larvae of two shank3 zebrafish mutant models and show that both models exhibit dampened responses to this...

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Identifiers

PMID: 34921227
DOI: 10.1038/s42003-021-02920-6
PMCID: PMC8683502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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