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Article

Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.

Cell - 8 Aug 2019

Orefice Lauren L, Mosko Jacqueline R, Morency Danielle T, Wells Michael F, Tasnim Aniqa, Mozeika Shawn M, Ye Mengchen, Chirila Anda M, Emanuel Alan J, Rankin Genelle, Fame Ryann M, Lehtinen Maria K, Feng Guoping, Ginty David D

Abstract excerpt

Somatosensory over-reactivity is common among patients with autism spectrum disorders (ASDs) and is hypothesized to contribute to core ASD behaviors. However, effective treatments for sensory over-reactivity and ASDs are lacking. We found distinct somatosensory neuron pathophysiological mechanisms underlie tactile abnormalities in different ASD mouse models and contribute to some ASD-related behaviors....

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Identifiers

PMID: 31398341
DOI: 10.1016/j.cell.2019.07.024
PMCID: PMC6704376

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