Article
SHANK3 mutations disrupt olfactory valence coding across species, with cortical amygdala mechanisms identified in mice.
Science advances - 8 May 2026
Hu Yu, Wu Yuli, Wei Mingyu, Ma Jingchao, Lin Jianbang, Chen Gaowei, Li Qi, Zhang Jianqing, Wang Ruiqi, Zhu Yingjie, Chen Qian, Peng Bo, Zou Yingying, Zhang Bo, Zhou Wen, Lu Zhonghua
Abstract excerpt
Mutations in SHANK3 are a leading monogenic cause of autism spectrum disorder (ASD), often associated with profound sensory abnormalities. However, the impact of SHANK3 deficiency on olfactory processing and the underlying neural mechanisms remains unclear. Here, we identify a cross-species disruption of olfactory valence perception in individuals with SHANK3 mutations and in Shank3 mutant mice. Patients carrying...
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