Article

Impaired cerebellar plasticity hypersensitizes sensory reflexes in <i>SCN2A</i> -associated ASD

2023-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Children diagnosed with autism spectrum disorder (ASD) commonly present with sensory hypersensitivity, or abnormally strong reactions to sensory stimuli. Such hypersensitivity can be overwhelming, causing high levels of distress that contribute markedly to the negative aspects of the disorder. Here, we identify the mechanisms that underlie hypersensitivity in a sensorimotor reflex found to be al...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0e29903-6b83-5ffc-86f0-f5978b1a2dfd
DOI: 10.1101/2023.06.05.543814

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impaired cerebellar plasticity hypersensitizes sensory reflexes in <i>SCN2A</i> -associated ASDDOI 10.1101/2023.06.05.543814Read

Altered cerebellar response to somatosensory stimuli in the <i>Cntnap2</i> mouse model of autismSemantic proximity Read

Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.Semantic proximity Read

CRISPR activation rescues abnormalities in <i>SCN2A</i> haploinsufficiency-associated autism spectrum disorderSemantic proximity Read

Excitatory Dysfunction and Phenotypic Rescue in a Human Neuronal Model of <i>SCN2A</i> -Related DisordersSemantic proximity Read

Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models.Semantic proximity Read

Whisker stimulation alleviate ASD behavior of BTBR mice by regulating Piezo2 expression in DRG and neuron function in S1 and mPFCSemantic proximity Read

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated <i>Scn2a</i> -deficiencySemantic proximity Read

Sensory processing dysregulations as reliable translational biomarkers in <i>SYNGAP1</i> haploinsufficiencySemantic proximity Read

Autism-associated <i>SCN2A</i> deficiency disrupts cortico-striatal circuitry in human brain assembloidsSemantic proximity Read

Restoring Shank3 in a rostral sensorimotor brainstem nucleus rescues reduced light-evoked behaviors in shank3ab-/- zebrafish.Semantic proximity Read

Sensory Reactivity Phenotype in Phelan-McDermid Syndrome Is Distinct from Idiopathic ASD.Semantic proximity Read

The Potential Effect of Nav1.8 in Autism Spectrum Disorder: Evidence from A Congenital Case with Compound Heterozygous SCN10A MutationsSemantic proximity Read