Article

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

2024-02-14

Abstract excerpt

A central problem in cancer immunotherapy with immune checkpoint blockade (ICB) is the development of resistance, which affects 50% of patients with metastatic melanoma 1,2 . T cell exhaustion, resulting from chronic antigen exposure in the tumour microenvironment, is a major driver of ICB resistance 3 . Here, we show that CD38, an ecto-enzyme involved in nicotinamide adenine dinucleotide (NAD + ) catabolism, i...

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Literature Corpus work: d6de604c-5fb7-51a7-b9e5-e8bc3468699e
DOI: 10.1101/2024.02.12.579184

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