Article

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

2023-03-23

Abstract excerpt

<h4>Summary</h4> The mitochondrial genome encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutation in the cancer genome, with truncating mutations in respiratory complex I genes being most over-represented 1 . While mitochondrial DNA (mtDNA) mutations have been associated with both improved and worsened prognoses in several tumou...

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Literature Corpus work: 8c80e4d3-d37c-53be-9520-07115380d6c2
DOI: 10.1101/2023.03.21.533091

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