Article

Intracellular K <sup>+</sup> limits T cell exhaustion and preserves antitumor function

2023-09-15

Abstract excerpt

The cancer-killing activity of T cells is often compromised within tumors, allowing disease progression. We previously found that intratumoral elevations in extracellular K + related to ongoing cell death constrained CD8 + T cell Akt-mTOR signaling and effector function (1,2). To alleviate K + mediated T cell suppression, we pursued genetic means to lower intracellular K + . Transcriptomic analysis of CD8 +...

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Literature Corpus work: 26a8fa43-ae00-5162-b8db-b05f7a1d6b42
DOI: 10.1101/2023.09.13.556997

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