Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma.

doi:10.1038/s43018-023-00721-w

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Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma.

Nature cancer - 1 Apr 2024

Mahmood Mahnoor, Liu Eric Minwei, Shergold Amy L, Tolla Elisabetta, Tait-Mulder Jacqueline, Huerta-Uribe Alejandro, Shokry Engy, Young Alex L, Lilla Sergio, Kim Minsoo, Park Tricia, Boscenco Sonia, Manchon Javier L, Rodríguez-Antona Crístina, Walters Rowan C, Springett Roger J, Blaza James N, Mitchell Louise, Blyth Karen, Zanivan Sara, Sumpton David, Roberts Edward W, Reznik Ed, Gammage Payam A

Abstract excerpt

The mitochondrial genome (mtDNA) encodes essential machinery for oxidative phosphorylation and metabolic homeostasis. Tumor mtDNA is among the most somatically mutated regions of the cancer genome, but whether these mutations impact tumor biology is debated. We engineered truncating mutations of the mtDNA-encoded complex I gene, Mt-Nd5, into several murine models of melanoma. These mutations promoted a...

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Identifiers

PMID: 38286828
DOI: 10.1038/s43018-023-00721-w
PMCID: PMC11056318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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