Article
Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma.
Journal of the National Cancer Institute - 1 Mar 2018
Audrito Valentina, Managò Antonella, La Vecchia Sofia, Zamporlini Federica, Vitale Nicoletta, Baroni Gianna, Cignetto Simona, Serra Sara, Bologna Cinzia, Stingi Aureliano, Arruga Francesca, Vaisitti Tiziana, Massi Daniela, Mandalà Mario, Raffaelli Nadia, Deaglio Silvia
Abstract excerpt
Background: One of the effects of oncogenic signaling is metabolic reprogramming of tumor cells to support anabolic growth, opening the way to therapeutic targeting of metabolic pathways. Methods: We studied NAD biosynthesis in BRAF inhibitor (BRAFi)-resistant (BiR) melanoma cell lines. Data in cell lines were confirmed by immunohistochemistry in biopsies from 17 patients with metastatic melanoma (MM) before and...
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