Article

TRIB2 supports a high glycolytic phenotype in melanoma cells

2025-11-18

Abstract excerpt

Metabolic adaptation plays a crucial role in driving the progression of human melanoma contributing to therapy resistance and disease relapse. The pseudo serine/threonine kinase Tribbles homolog 2 (TRIB2) is prominently expressed in melanoma tissue, promoting resistance to anti-cancer treatments and correlating with unfavorable clinical outcomes. Despite this understanding, the impact of TRIB2 expression on melano...

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Literature Corpus work: 860a14b7-5e60-5f6f-aa1c-50dd30d03162
DOI: 10.1101/2025.11.18.689112

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