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Single‐Cell RNA ‐Seq Reveals Injuries in Aortic Dissection and Identifies PDGF Signalling Pathway as a Potential Therapeutic Target

1 Dec 2024

Abstract excerpt

ABSTRACT Aortic dissection (AD) represents a critical condition characterised by a tear in the inner lining of the aorta, leading to the leakage of blood into the layers of the aortic wall, posing a significant risk to life. However, the pathogenesis is unclear. In this study, scRNA‐seq was applied to cells derived from aortas of both AD and non‐AD donors (control) to unveil the cellular landscape. ScRNA‐seq data...

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PMID: 39720896
DOI: 10.1111/jcmm.70293

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