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Article

Leveraging genetic propensity to identify modifiable factors for the age at onset of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2026

Li Yi-Ju, La Jong Ok, Naj Adam, Martin Eden R

Abstract excerpt

INTRODUCTION: Knowledge of modifiable factors influencing age at onset (AAO) of Alzheimer's disease (AD) remains limited. This study utilizes genetic information to uncover such factors. METHODS: Using 43 exposure genome-wide association studies (GWAS) summary statistics, we calculated corresponding polygenic scores (PGS) for 9219 AD cases and 10,345 controls from the Alzheimer's Disease Genetic Consortium...

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Identifiers

PMID: 41656167
DOI: 10.1002/alz.71111
PMCID: PMC12883339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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