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Article

Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease.

Neurobiology of aging - 1 Feb 2018

Chaudhury Sultan, Patel Tulsi, Barber Imelda S, Guetta-Baranes Tamar, Brookes Keeley J, Chappell Sally, Turton James, Guerreiro Rita, Bras Jose, Hernandez Dena, Singleton Andrew, Hardy John, Mann David, Morgan Kevin

Abstract excerpt

Sporadic early-onset Alzheimer's disease (sEOAD) exhibits the symptoms of late-onset Alzheimer's disease but lacks the familial aspect of the early-onset familial form. The genetics of Alzheimer's disease (AD) identifies APOEε4 to be the greatest risk factor; however, it is a complex disease involving both environmental risk factors and multiple genetic loci. Polygenic risk scores (PRSs) accumulate the total risk...

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Identifiers

PMID: 29103623
DOI: 10.1016/j.neurobiolaging.2017.09.035
PMCID: PMC5995122

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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