Article

Necrosis drives susceptibility to <i>Mycobacterium tuberculosis</i> in Polg <sup>D257A</sup> mutator mice

2024-07-22

Abstract excerpt

<h4>ABSTRACT</h4> The genetic and molecular determinants that underlie the heterogeneity of Mycobacterium tuberculosis (Mtb) infection outcomes in humans are poorly understood. Multiple lines of evidence demonstrate that mitochondrial dysfunction can exacerbate mycobacterial disease severity and mutations in some mitochondrial genes confer susceptibility to mycobacterial infection in humans. Here, we report that...

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Literature Corpus work: d6afb1bb-de5e-5ecc-9001-ad7f402ae46a
DOI: 10.1101/2024.07.17.603991

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Necrosis drives susceptibility to <i>Mycobacterium tuberculosis</i> in Polg <sup>D257A</sup> mutator miceDOI 10.1101/2024.07.17.603991Read

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