Article
Necrosis drives susceptibility to Mycobacterium tuberculosis in PolgD257A mutator mice.
Infection and immunity - 11 Mar 2025
Mabry C J, Weindel C G, Stranahan L W, VanPortfliet J J, Davis J R, Martinez E L, West A P, Patrick K L, Watson R O
Abstract excerpt
The genetic and molecular determinants that underlie the heterogeneity of Mycobacterium tuberculosis (Mtb) infection outcomes in humans are poorly understood. Multiple lines of evidence demonstrate that mitochondrial dysfunction can exacerbate mycobacterial disease severity, and mutations in some mitochondrial genes confer susceptibility to mycobacterial infection in humans. Here, we report that mutations in...
Read the complete abstract on PubMedTopics
- Animals
- Mycobacterium tuberculosis
- Mice
- Necrosis
- Mutation
- Tuberculosis
- Macrophages