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Article

BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility

8 Dec 2023

Abstract excerpt

Abstract Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, a transcription factor that represses multiple antioxidant genes, regulates host resistance to Mtb. We found that BACH1 expression is associated clinically with active pulmonary...

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PMID: 38066332
DOI: 10.1038/s41564-023-01523-7

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