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Multimodal profiling reveals <i>Mycobacterium tuberculosis</i> restricts lung mitochondrial immunometabolism to promote pathogenesis

2026-04-10

Abstract excerpt

Early events in the lung that shape protective immune responses to M. tuberculosis (Mtb) infection are not well understood but are critical for developing better vaccines and immunomodulatory therapies for tuberculosis. Here, we used high-dimensional flow cytometry, single-cell transcriptomics, and untargeted metabolomics to define the early lung immune environment that precedes the development of protective vers...

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Literature Corpus work
b8cadd0f-0d08-5101-96d2-3bd3468c9430
DOI
10.64898/2026.04.07.717012
Open publication

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Multimodal profiling reveals <i>Mycobacterium tuberculosis</i> restricts lung mitochondrial immunometabolism to promote pathogenesisDOI 10.64898/2026.04.07.717012
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