Article

The cGAS-STING pathway regulates microglial chemotaxis in genome instability

2023-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Defective DNA damage signalling and repair is a hallmark of age-related and genetic neurodegenerative disease. One mechanism implicated in disease progression is DNA damage-driven neuroinflammation, which is largely mediated by tissue-resident immune cells, microglia. Here, we utilise human microglia-like cell models of persistent DNA damage and ATM kinase deficiency to investigate how genome in...

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Literature Corpus work: d6af3594-1542-5bca-a3d6-7a7c83876805
DOI: 10.1101/2023.08.25.554654

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