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Article

DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity

13 Mar 2023

Abstract excerpt

Abstract The immunoproteasome is a specialized type of proteasome involved in MHC class I antigen presentation, antiviral adaptive immunity, autoimmunity, and is also part of a broader response to stress. Whether the immunoproteasome is regulated by DNA stress, however, is not known. We here demonstrate that mitochondrial DNA stress upregulates the immunoproteasome and MHC class I antigen presentation pathway via...

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Identifiers

PMID: 36912165
DOI: 10.15252/embj.2022110597

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