Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost

24 Sept 2013

Abstract excerpt

Cell and tissue polarity are tightly coupled and are vital for normal tissue homeostasis. Changes in cellular and tissue organization are common to even early stages of disease, particularly cancer. The digestive tract is the site of the second most common cause of cancer deaths in the developed world. Tumours in this tissue arise in an epithelium that has a number of axes of cell and tissue polarity. Changes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Digestive system and related health
Share to Hippo pathway signaling and YAP/TAZ

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24062584
DOI: 10.1098/rstb.2013.0014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lostPMID 24062584Read ↗

Gut organoids: mini-tissues in culture to study intestinal physiology and diseaseSemantic proximity Read ↗

Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseasesSemantic proximity Read ↗

Organoids and Colorectal CancerSemantic proximity Read ↗

The Intestinal Epithelium – Fluid Fate and Rigid Structure From Crypt Bottom to Villus TipSemantic proximity Read ↗

Shortcuts to intestinal carcinogenesis by genetic engineering in organoidsSemantic proximity Read ↗

Patient-derived organoids identify an apico-basolateral polarity switch associated with survival in colorectal cancerSemantic proximity Read ↗

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations.Semantic proximity Read ↗

Organoids and Their Use in Modeling Gut Epithelial Cell Lineage Differentiation and Barrier Properties During Intestinal DiseasesSemantic proximity Read ↗

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation.Semantic proximity Read ↗

Creating a More Perfect Union: Modeling Intestinal Bacteria-Epithelial Interactions Using OrganoidsSemantic proximity Read ↗

Intestinal multicellular organoids to study colorectal cancerSemantic proximity Read ↗

Intestinal Morphogenesis in Development, Regeneration, and Disease: The Potential Utility of Intestinal Organoids for Studying Compartmentalization of the Crypt-Villus StructureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.