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Article

Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.

The Journal of pathology - 1 Jul 2018

Morris Hayley T, Fort Loic, Spence Heather J, Patel Rachana, Vincent David F, Park James H, Snapper Scott B, Carey Francis A, Sansom Owen J, Machesky Laura M

Abstract excerpt

N-WASP (WASL) is a widely expressed cytoskeletal signalling and scaffold protein also implicated in regulation of Wnt signalling and homeostatic maintenance of skin epithelial architecture. N-WASP mediates invasion of cancer cells in vitro and its depletion reduces invasion and metastatic dissemination of breast cancer. Given this role in cancer invasion and universal expression in the gastrointestinal tract, we...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29672847
DOI: 10.1002/path.5086
PMCID: PMC6033012

Genes

WASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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