Article

Dissecting Small Noncoding RNA Landscapes in Mouse Preimplantation Embryos and Human Blastoids for Modeling Early Human Embryogenesis

2025-10-07

Abstract excerpt

<h4>Summary</h4> Small non-coding RNAs (sncRNA) exert regulatory functions in mammalian cells; however, their expression dynamics and contribution during preimplantation development are not entirely understood. In this study, we apply Small-Seq to generate a comprehensive single-cell atlas of sncRNA expression in mouse oocytes, sperm, and embryos (2-cell to 64-cell stages), and compare these dynamics with human e...

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Literature Corpus work: 1ba59b43-f7fd-57f8-b86a-9292ffab1552
DOI: 10.1101/2025.10.07.680944

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